Andrew P. Steenhoff

3 weeks ago | nature.com | Matthew Kelly |Andrew P. Steenhoff |Coleen K. Cunningham |John Rawls |Jillian H. Hurst

AbstractThe mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 infants enrolled in a prospective cohort study in Botswana, we perform a detailed analysis of factors that influence the dynamics of bacterial pathobiont colonization during infancy. We quantify the extent to which viruses increase the acquisition of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae.