Andria Mousa

1 week ago | nature.com | Andria Mousa |Gina Cuomo-Dannenburg |Karen Barnes |Jaishree Raman |Ana Chopo-Pizarro |R. Matthew Chico | +2 more

AbstractSulfadoxine-pyrimethamine (SP) is recommended for perennial malaria chemoprevention in young children in high burden areas across Africa. Mutations in the dihydropteroate synthase (dhps) gene (437 G/540E/581 G) associated with sulfadoxine resistance vary regionally, but their effect on SP protective efficacy is unclear. We retrospectively analyse time to microscopy and PCR-confirmed re-infection in seven efficacy trials including 1639 participants in 12 sites across Africa.

May 9, 2024 | journals.plos.org | Andria Mousa |Tropical Diseases |Gina Cuomo-Dannenburg |Hayley Thompson

Citation: Mousa A, Cuomo-Dannenburg G, Thompson HA, Chico RM, Beshir KB, Sutherland CJ, et al. (2024) Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology. PLoS Med 21(5): e1004376. https://doi.org/10.1371/journal.pmed.1004376Academic Editor: Peter MacPherson, University of Glasgow, UNITED KINGDOMReceived: September 8, 2023; Accepted: March 14, 2024; Published: May 9, 2024Copyright: © 2024 Mousa et al.