Aneta H. Worley

Feb 23, 2024 | nature.com | Corinna A. Kulicke |Gwendolyn M. Swarbrick |Aneta H. Worley |Fikadu Tafesse |Andrew Olive |William Hildebrand | +5 more

AbstractMR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways. To investigate ligand exchange pathways for MR1, we used MR1 monomers and tetramers loaded with 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) to deliver the antigen.