Anette Breindl

1 week ago | bioworld.com | Anette Breindl

Home » Precision medicine approach identifies culprit in alcohol-associated hepatitisGastrointestinalPrecision medicine approach identifies culprit in alcohol-associated hepatitisResearchers have identified KpsM as a virulence factor in Escherichia coli that was responsible for liver damage in alcohol-associated hepatitis (AH). A small-molecule inhibitor of KpsM reduced liver damage in animal models of AH. BioWorld Science Gastrointestinal Immune

1 week ago | bioworld.com | Anette Breindl

Individuals with both sickle cell disease (SCD) and sickle cell trait are at higher risk than others of developing renal medullary cancer (RMC), the rarest and deadliest subtype of kidney cancer. Researchers at MD Anderson Cancer Center have identified the molecular mechanisms behind the increased risk, gaining new insights into antitumor immunity more generally and, potentially, new ways to treat RMC, and possibly other tumors as well.

2 weeks ago | bioworld.com | Anette Breindl

ASGCT 2025First bespoke gene editing therapy treats rare metabolic diseaseUsing a customized gene editing therapy, researchers at the Children’s Hospital of Philadelphia have reported success in treating an infant with a severe metabolic disorder. Kiran Musunuru, Barry J. Gertz Professor for Translational Research in the University of Pennsylvania’s Perelman School of Medicine, presented the case at the American Society of Gene and Cell Therapy’s 2025 annual meeting.

3 weeks ago | bioworld.com | Anette Breindl

ASGCT 2025First bespoke gene editing therapy treats rare metabolic diseaseUsing a customized gene editing therapy, researchers at the Children’s Hospital of Philadelphia have reported success in treating an infant with a severe metabolic disorder. Kiran Musunuru, Barry J. Gertz Professor for Translational Research in the University of Pennsylvania’s Perelman School of Medicine, presented the case at the American Society of Gene and Cell Therapy’s 2025 annual meeting.

3 weeks ago | bioworld.com | Anette Breindl

Endocrine/metabolicLiver is also immune organ, influenced by microbiomeImmunity is not a function most people particularly associate with the liver. But because of its connection to the gut, the liver is exposed to bacterial metabolites as few other organs are. And when either the liver or the gut is not functioning well, it can adversely affect immunity as well. BioWorld MedTech Science Conferences Microbiome Endocrine/metabolic Gastrointestinal Immune