Anshuman Jaysingh

May 14, 2024 | biorxiv.org | Olivia L Mooren |Patrick McConnell |James D DeBrecht |Anshuman Jaysingh

AbstractActin polymerization is often associated with membrane proteins containing capping-protein-interacting (CPI) motifs, such as CARMIL, CD2AP, and WASHCAP/Fam21. CPI motifs bind directly to actin capping protein (CP), and this interaction weakens the binding of CP to barbed ends of actin filaments, lessening the ability of CP to functionally cap those ends. The protein V-1 / myotrophin binds to the F-actin binding site on CP and sterically blocks CP from binding barbed ends.