Anton Safonov

Nov 11, 2024 | cell.com | Rei Kudo |Anton Safonov |Catherine Jones |Jonathan R. Dry

Main text(Cancer Cell , 1919–1935.e9; November 11, 2024)We, the authors of this paper, recently reported that loss of in hormone receptor-positive breast cancer associated with long-term failure to CDK4/6 inhibitors due to geroconversion. Upon online publication of the article, we realized that we had inadvertently omitted Iker Huerga Sanchez (I.H.S.) from the author list.

Oct 17, 2024 | nature.com | Nicholas Mai |Pedram Razavi |Anton Safonov |Chau Dang |Larry Norton |Mark E. Robson | +1 more

AbstractAfter disease progression on endocrine therapy (ET) plus a CDK4/6 inhibitor, there is no standardized sequence for subsequent treatment lines for estrogen receptor positive (ER+) metastatic breast cancer (MBC). CDK4/6i retrial as a treatment strategy is commonplace in modern clinical practice; however, the available prospective data investigating this strategy have had inconclusive results.

Oct 10, 2024 | cell.com | Rei Kudo |Anton Safonov |Catherine Jones |Jonathan R. Dry

SA- β-gal assaysCells were treated with DMSO, 50 nM abemaciclib or 500 nM evbaciclib for 5–8 days. Cells were harvested using trypsin/EDTA and then stained with the CellEvent Senescence Green Flow Cytometry Assay Kit (Invitrogen, C10840) according to the manufacturer’s instructions. Briefly, cells were fixed with 2% paraformaldehyde for 15 min at room temperature and stained with the CellEvent Senescence Green Probe for 2 h at 37°C without CO2.

May 1, 2024 | biorxiv.org | Avantika Gupta |Andrea Gazzo |Pier Selenica |Anton Safonov

AbstractAcquired genetic alterations commonly drive resistance to endocrine and targeted therapies in metastatic breast cancer, however the underlying processes engendering these diverse alterations are largely uncharacterized. To identify the mutational processes operant in breast cancer and their impact on clinical outcomes, we utilized a well-annotated cohort of 3,880 patient samples with paired tumor-normal sequencing data.