Antonia Wagener

Sep 13, 2024 | cell.com | Bianca Martin |Maria Cadefau-Fabregat |Antonia Wagener |Christina Budden

Keywords SCFA butyrate propionate inflammasome NLRP3 IL-10 caspase-8 HDAC acetylation cFLIP Research topic(s) CP: Immunology Introduction Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are generated at high concentrations by the microbiota through fermentation of dietary fiber.1 This occurs in the intestine, where concentrations can range from 10 to 90 mM at a ratio of 3:1:1 acetate:propionate:butyrate, as well as in the periodontal pockets in the mouth.1,2...