Aochiu Chen

Sep 8, 2023 | pubs.rsc.org | Michael D. Burkart |Ziran Jiang |Aochiu Chen |Jeffrey Chen

Masked Cerulenin Enables a Dual-Site Selective Protein Crosslink Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for their value as therapeutic candi-dates, due to their ability to selectively react with catalytic residues within a protein active site or a complex of protein domains. Here, we explore the development of fatty-acid and polyketide-synthase probes by synthetically modulating cerulenin’s functional moieties.