Aram Vosoughi

Mar 17, 2024 | nature.com | André Figueiredo Rendeiro |Hiranmayi Ravichandran |Aram Vosoughi |Shaham Beg |David Wilkes |Brian Robinson | +5 more

AbstractThe molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not well understood, and there is a lack of knowledge regarding the genomic and transcriptomic differences between primary and metastatic UTUC. To address these gaps, we integrate whole-exome sequencing, RNA sequencing, and Imaging Mass Cytometry using lanthanide metal-conjugated antibodies of 44 tumor samples from 28 patients with high-grade primary and metastatic UTUC.