Armin Bayati

Sep 1, 2024 | jbc.org | Armin Bayati |Peter McPherson

Parkinson’s diseaseParkinson’s disease (PD) is the second most common neurodegenerative disease, characterized by motor symptoms such as bradykinesia, dystonia, rigidity, postural instability, and resting tremors 1. A whole host of nonmotor symptoms, such as depression, anxiety, cognitive impairment, and several gastrointestinal-related impairments, also accompany PD 2.

Aug 21, 2024 | nature.com | Emily Banks |Sheng-Jia Lin |Vladimir S. Fonov |Maxime Lévesque |Armin Bayati |Fowzan S. Alkuraya | +28 more

AbstractDevelopmental and epileptic encephalopathies (DEEs) feature altered brain development, developmental delay and seizures, with seizures exacerbating developmental delay. Here we identify a cohort with biallelic variants in DENND5A, encoding a membrane trafficking protein, and develop animal models with phenotypes like the human syndrome.