Ashley Hoffman

Aug 22, 2024 | digitalcommons.library.tmc.edu | Shan Wang |Ashley Hoffman |Suchan Niroula |Melika Khorrami

CFTR (cystic fibrosis transmembrane conductance regulator) modulator drugs restore function to mutant channels in patients with cystic fibrosis (CF) and lead to improvements in body mass index and lung function.

May 31, 2024 | digitalcommons.library.tmc.edu | Shan Wang |Wei Rao |Ashley Hoffman |Jennifer Lin

AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial lung disease marked by the replacement of lung alveoli with dense fibrotic matrices. Although the mechanisms initiating IPF remain unclear, rare and common alleles of genes expressed in lung epithelia, combined with aging, contribute to the risk for this condition.