Ashraf Broury

Feb 5, 2024 | nature.com | Steven Lim |Sarah L. Snelgrove |Eric F. Morand |Peter J. Eggenhuizen |Khai L. Loh |Ashraf Broury

AbstractAntigen-specific regulatory T cells (Tregs) suppress pathogenic autoreactivity and are potential therapeutic candidates for autoimmune diseases such as systemic lupus erythematosus (SLE). Lupus nephritis is associated with autoreactivity to the Smith (Sm) autoantigen and the human leucocyte antigen (HLA)-DR15 haplotype; hence, we investigated the potential of Sm-specific Tregs (Sm-Tregs) to suppress disease.