Ashwin Jainarayanan

Aug 15, 2024 | biorxiv.org | Jesusa Capera |Ashwin Jainarayanan |Salvatore Valvo |Lina Chen

AbstractInterleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. T cells fine-tune their sensitivity to and consumption of IL2 by regulating surface expression and composition of the IL2 receptor. Following antigen recognition, IL2 receptor signalling is shared through polarized interactions in T cell aggregates. However, how IL2 function is integrated during earlier antigen-dependent T cell synapses is unknown.