Astrid Hagelkrüys

Feb 16, 2024 | nature.com | Gustav Jönsson |Jun Wang |Camille Laporte |David Long |Christophe Battail |Astrid Hagelkrüys | +2 more

AbstractThe development of vascular networks in microfluidic chips is crucial for the long-term culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or tissue explants. Despite rapid advancement in microvascular network systems and organoid technologies, vascularizing organoids-on-chips remains a challenge in tissue engineering. Most existing microfluidic devices poorly reflect the complexity of in vivo flows and require complex technical set-ups.

Oct 25, 2023 | nature.com | Vanessa Monteil |Hyesoo Kwon |Cristiano Salata |Gustav Jönsson |Sofia Appelberg |Astrid Hagelkrüys | +7 more

AbstractMarburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication.