Athanassios Dovas

Jan 20, 2025 | cell.com | Alexander R. Goldberg |Athanassios Dovas |Daniela Torres |Brianna Pereira |Ashwin Viswanathan |Sohani Das Sharma | +33 more

Keywordsgliomaglioma microenvironmentexcitatory neuronsmTOR inhibitionglioma-associated neuronal alterationsglioma-induced plasticitydendritic spinesneuronal hyperexcitabilitybrain tumorsalterations in neuronal activitybrain tumor microenvironmentGet full text accessLog in, subscribe or purchase for full access. References1. Rudà, R. ∙ Bello, L. ∙ Duffau, H. ... Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatmentsNeuro-Oncology. 2012; 14:iv55-iv642. Klein, M.

Jun 9, 2024 | biorxiv.org | Steven Rosenfeld |Natanael Zarco |Athanassios Dovas |Virginea Farias

AbstractWhile mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therapy induced senescent cells that resist these drugs by relying upon the anti-apoptotic and metabolic effects of activated STAT3.