Atsumi Tsuji-Hosokawa

Oct 22, 2024 | journals.physiology.org | Qiuyu Zheng |Atsumi Tsuji-Hosokawa |Francisco Ramírez |Hua Cai

Metabolic abnormalities in pulmonary endothelial cells are implicated in pulmonary hypertension (PH) while increasing evidence shows the influence of diabetes on progressing PH. In this study, we examined the effect of type 2 diabetes on hypoxia-induced PH and investigated its molecular mechanisms using hypoxia-induced diabetic male mice. Chronic hypoxia led to a more severe PH in type 2 diabetic mice than in control mice.