Aurélie Zbinden

Jul 11, 2023 | embopress.org | Manuela Pérez-Berlanga |Vera I. Wiersma |Aurélie Zbinden |Laura De Vos

Loss of RNA binding or oligomerization differentially modulate the subcellular localization of TDP-43 inclusions Decline of the cellular proteostasis capacity with age contributes to protein misfolding in neurodegenerative diseases (Jayaraj et al, 2020), often resulting in the accumulation of ubiquitinated inclusions in affected tissues, including TDP-43 proteinopathies (Arai et al, 2006; Neumann et al, 2006).