Ayeisha Milligan Armstrong

Oct 15, 2024 | biorxiv.org | Melissa K Eccles |Amy Woodfield |Ayeisha Milligan Armstrong |Mark Agostino

AbstractPresenilin proteins, the catalytic components of the γ-secretase enzyme, play a key role in the pathogenesis of Alzheimer's disease primarily by generating amyloid-β peptides. Although often grouped together, Presenilin-1 (PS1) and Presenilin-2 (PS2) are distinct proteins that contribute differently to γ-secretase activity.