Azadeh Hatef

Mar 20, 2024 | biorxiv.org | Atefeh Nasri |Emilio Vélez |Jithine Jayakumar Rajeswari |Azadeh Hatef

AbstractBackground: Nesfatin-1 (NESF-1), encoded in the calcium and DNA binding protein (Nucleobindin 2, NUCB2) is an orphan ligand with metabolic effects. Recently, our lab provided evidence for a NESF-1-like peptide (NLP) in a NUCB2-related precursor, NUCB1, in zebrafish and rodents. This research aims to determine whether endogenous NUCB1 is critical for energy homeostasis.