Azienda Sanitaria Territoriale

Jul 12, 2023 | frontiersin.org | Azienda Sanitaria Territoriale |Anne Lise |Laura Maggi |Antonio Condino-Neto

IntroductionCommon variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency characterized by low immunoglobulin (Ig) levels (IgG and/or IgM) and impaired production of specific antibodies in response to vaccinations (1, 2). CVID is a heterogeneous disorder (3, 4) with a presumed multifactorial etiology and an estimated heritability of approximately 20% (2, 5–7).