Baktiar Karim

Sep 26, 2024 | biorxiv.org | Ashwin nair |David Davis |Andrew Warner |Baktiar Karim

AbstractThe spindle cells of Kaposi sarcoma (KS) lesions primarily express Kaposi sarcoma herpesvirus (KSHV) latent genes with minimal expression of lytic genes. However, recent transcriptome analyses of KS lesions have shown high expression of KSHV open reading frame (ORF) 75, which is considered a late lytic gene based on analyses in primary effusion lymphoma (PEL) lines.

Jul 29, 2024 | biorxiv.org | Srikanta Basu |Brian Luke |Baktiar Karim |Nancy Martin

AbstractOncogenic RAS induces perinuclear translocation of the effector kinases ERK and CK2 and their scaffold, KSR1, forming endosomal signaling hubs termed perinuclear signaling centers (PSCs). PSCs are present in all cancer cell lines and tissues examined, suggesting that subcellular compartmentalization of oncogenic kinases drives tumorigenesis.