Barnaby C. Reeves

Apr 26, 2024 | octnews.org | Sean O’Connor |Barnaby C. Reeves

April 26, 2024 | Ophthalmology | Queen's University Belfast, University of Bristol, University of Liverpool, University of Southampton Importance  Most neovascular age-related macular degeneration (nAMD) treatments involve long-term follow-up of disease activity. Home-monitoring would reduce the burden on patients and their caregivers and release clinic capacity.

Jan 25, 2024 | bmjopen.bmj.com | Barnaby C. Reeves |chris rogers |Katie Pike |Lucy A Culliford

Methods and analysisThe ASTUTE trial is a multicentre, parallel-group, placebo-controlled, pragmatic RCT with a treatment run-in (TRI). In the TRI, eligible participants will receive open-label adalimumab for 16 weeks. At 16 weeks, participants will be assessed, and only those classified as having a therapeutic response will be randomised. The study schema is shown in figure 1. The target population is adults with active or controlled ANIU.