Behnaz Eftekhari

Nov 29, 2024 | cell.com | Fitzroy J. Byfield |Behnaz Eftekhari |Kaeli Kaymak-Loveless |Kalpana Mandal |David Li |Rebecca Wells | +6 more

1Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104-6383, USA 2Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104-6383, USA 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6383, USA 4Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6383, USA 5NSF Science and Technology Center for Engineering MechanoBiology, University of...

Apr 16, 2024 | biorxiv.org | Fitzroy J. Byfield |Kalpana Mandal |Behnaz Eftekhari |Kaeli Kaymak-Loveless

AbstractThe structure and dynamics of the cell nucleus regulate nearly every facet of the cell. Changes in nuclear shape limit cell motility and gene expression. Although the nucleus is generally seen as the stiffest organelle in the cell, cells can nevertheless deform the nucleus to large strains by small mechanical stresses. Here, we show that the mechanical response of the cell nucleus exhibits active fluidization that is driven by the BRG 1 motor of the SWI/SNF/BAF chromatin-remodeling complex.