Ben Vanderkruk

Oct 7, 2024 | nature.com | Ben Vanderkruk |Samantha Mar |Shugo Sasaki |Thilo Speckmann |Stefan Taubert |Bradford G. Hoffman

AbstractMediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrine hormone-producing pancreatic islets isolated from people living with type 2 diabetes and sought to understand how MED15 and Mediator control gene expression programs important for the function of insulin-producing β-cells.