Benjamin A. Barad

Sep 18, 2023 | nature.com | Alexander Wolff |Eriko Nango |Aaron Brewster |Minoru Kubo |Benjamin A. Barad |Kazutaka Ito | +9 more

AbstractUnderstanding and controlling protein motion at atomic resolution is a hallmark challenge for structural biologists and protein engineers because conformational dynamics are essential for complex functions such as enzyme catalysis and allosteric regulation. Time-resolved crystallography offers a window into protein motions, yet without a universal perturbation to initiate conformational changes the method has been limited in scope.