Benjamin T. Bikman

Oct 26, 2024 | scholarsarchive.byu.edu | Kate Erickson |Benjamin T. Bikman |Brigham Young

KeywordsAMP-activated protein kinase, AMPK, de novo ceramide biosynthesisDepartmentPhysiology and Developmental BiologyAbstractThe purpose of this project was to determine the cellular mechanisms that mediate AMPK-induced reductions in lipotoxicity. We predicted that AMPK activation inhibits lipotoxic ceramide biosynthesis via targeted reduction in transcription of a critical, rate-limiting enzyme involved in de novo ceramide synthesis.

Jan 26, 2024 | scholarsarchive.byu.edu | Brian Parker |Benjamin T. Bikman |Brigham Young

KeywordsB-hydroxybutyrate favorably, muscle cell survival, mitochondrial bioenergeticsDepartmentPhysiology and Developmental BiologyAbstractThe growing worldwide incidence of obesity and its associated pathologies, like type 2 diabetes, has received much deserved attention. However, despite this attention and substantial research efforts, little meaningful progress has been made in slowing or reversing the growing cost and trends of obesity worldwide.