Bernardo L. Sabatini

Jul 25, 2024 | nature.com | Samuel J. Gershman |Sandeep Robert Datta |Scott Linderman |Bernardo L. Sabatini |Naoshige Uchida

AbstractThe most influential account of phasic dopamine holds that it reports reward prediction errors (RPEs). The RPE-based interpretation of dopamine signaling is, in its original form, probably too simple and fails to explain all the properties of phasic dopamine observed in behaving animals. This Perspective helps to resolve some of the conflicting interpretations of dopamine that currently exist in the literature.

Feb 5, 2024 | nature.com | Bernardo L. Sabatini

AbstractIntracellular signaling dynamics play a crucial role in cell function. Protein kinase A (PKA) is a key signaling molecule that has diverse functions, from regulating metabolism and brain activity to guiding development and cancer progression. We previously developed an optical reporter, FLIM-AKAR, that allows for quantitative imaging of PKA activity via fluorescence lifetime imaging microscopy and photometry.

Jul 17, 2023 | cell.com | Michael Wallace |Bernardo L. Sabatini

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