Binbin Yuan

Dec 27, 2023 | bpspubs.onlinelibrary.wiley.com | Ying Xu |Jian Tang |Binbin Yuan |Xuemei Luo

ARC augmented renal clearance AVI avibactam BL β-lactam/β-lactamase inhibitor combination CAZ ceftazidime CAZ-AVI ceftazidime-avibactam CI continuous infusion CLCr creatinine clearance CRKP carbapenem-resistant Klebsiella pneumoniae CRPA carbapenem-resistant Pseudomonas aeruginosa Css steady-state concentration CVVHDF continuous venovenous haemodiafiltration DALI The Defining Antibiotic Levels in Intensive Care Unit Patients MDR multidrug-resistant MIC minimum inhibitory concentration PD...

Sep 25, 2023 | onlinelibrary.wiley.com | Agnese Zangarelli |Binbin Yuan |Lutz Ackermann

In recent decades, transition metal-catalyzed selective C−H bond functionalization has become an indispensable, cutting-edge step- and atom-economical1 approach for the design of highly useful bioactive pharmaceuticals.2 Within this framework, indoles and their substituted derivatives have emerged as one of the most researched classes of organic compounds, given their use as functional building blocks in numerous marketed drugs and molecular materials (Figure 1a).3 As a precursor, indole...

Sep 21, 2023 | chemistry-europe.onlinelibrary.wiley.com | Elisa Y. Lai |Binbin Yuan |Lutz Ackermann |Magnus Johansson

Introduction Introducing amide functional groups under mild conditions has growing importance due to the ubiquity of such structures in biologically active molecules such as peptides and proteins.