Bram Bussin

1 month ago | nature.com | Bram Bussin |Wayne Ngo |Adrian Granda Farias |Benjamin Stordy |Sara Ahmed |Jason Moffat

AbstractLiver macrophages capture circulating nanoparticles and reduce their delivery to target organs. Serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloodstream have not been linked. Here we use a multi-omics strategy to identify the adsorbed serum proteins binding to specific liver macrophage receptors.