Brandon Hughes

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NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens - Nature Communications

Aug 8, 2024 | nature.com | Brandon Hughes |Michael Scofield |Stefano Berto |Makoto Taniguchi

AbstractPowerful associations that link drugs of abuse with cues in the drug-paired environment often serve as prepotent relapse triggers. Drug-associated contexts and cues activate ensembles of nucleus accumbens (NAc) neurons, including D1-class medium spiny neurons (MSNs) that typically promote, and D2-class MSNs that typically oppose, drug seeking.

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