Branko Cuglievan

Houston

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Menin inhibitors in pediatric acute leukemia: a comprehensive review and recommendations to accelerate progress in collaboration with adult leukemia and the international community | Leukemia

Aug 23, 2024 | nature.com | Branko Cuglievan |Hagop Kantarjian |Courtney DiNardo |Tapan M Kadia |Erin Guest |Nicholas Short | +18 more

AbstractAberrant expression of HOX and MEIS1 family genes, as seen in KMT2A-rearranged, NUP98-rearranged, or NPM1-mutated leukemias leads to arrested differentiation and leukemia development. HOX family genes are essential gatekeepers of physiologic hematopoiesis, and their expression is regulated by the interaction between KMT2A and menin.

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