Brendan N Schweitzer

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Repeated administration of pharmaceutical-grade medium chain triglycerides, a common pharmacologic excipient, confers dose-dependent toxicity by the intraperitoneal but not oral route in mice

Nov 26, 2024 | biorxiv.org | Julia Tsai |Ashley McDonough |Mitzi Adler-Wachter |Brendan N Schweitzer

AbstractPharmaceutical-grade medium chain triglycerides (MCTs) are common excipients for in vivo pharmacological studies in laboratory animals, and as an experimental therapeutic in certain metabolic and neurological disorders. In this study, we examined the tolerability of repeated administration of a pharmaceutical-grade formulation of three MCTs (caprylic, capric, and lauric acid) in mice via the oral (PO) and intraperitoneal (IP) routes.

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