Brian A. Droz

Jan 7, 2025 | cell.com | Xinxin Yu |Shiuhwei Chen |Jan-Bernd Funcke |Leon G. Straub |Valentina Pirro |Margo P. Emont | +15 more

KeywordsGIP receptoradipose tissueobesityweight lossenergy expenditureSERCA pathwayIntroductionThe prevalence of obesity has substantially increased. The World Health Organization recognizes obesity as a worldwide epidemic and a major disease of the 21st century, with >4 million people dying in 2017.1 Obesity is characterized as excessive fat accumulation that presents a health risk, which results from a dysregulation in energy homeostasis, i.e., caloric intake exceeding energy expenditure.

Dec 18, 2024 | science.org | Kyle W Sloop |Amy Cox |David B. Wainscott |Alex White |Brian A. Droz |Aaron Showalter | +9 more

Published In Science Translational MedicineVolume 16 | Issue 778December 2024Article versionsSubmission historyReceived: 5 April 2024Resubmitted: 24 June 2024Accepted: 20 November 2024PermissionsRequest permissions for this article. AcknowledgmentsWe thank B. Czeskis, J. Ficorilli, M. Herrera, A. MacFarland, and Y. Qian for technical support. We thank A. Bueno, K. Burris, M. Coghlan, A. Konkar, K. Lansu, J. Moyers, and R. Samms for helpful discussions during the preparation of the manuscript.