Brian A. Vesely

Mar 19, 2024 | nature.com | Bing Guo |Víctor Borda |Brian A. Vesely |Joana Silva |Timothy O’Connor

AbstractMalaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based estimates. In this study, we use simulations, a true IBD inference algorithm, and empirical data sets from different malaria transmission settings to investigate the extent of this bias and explore potential correction strategies.