Bryan A. Comstock

Apr 4, 2023 | mdpi.com | Krystle Perez |Mihai Puia-Dumitrescu |Bryan A. Comstock |Thomas Wood

1. IntroductionSepsis remains a leading cause of neonatal death, especially among those born prematurely [1,2]. Infection has been implicated as a contributor to more than 10% of deaths among extremely preterm (EP) infants [3].

Apr 3, 2023 | jpeds.com | Sandra E. Juul |Bryan A. Comstock |Marie-Coralie Cornet

To assess whether high dose erythropoietin (Epo) treatment of cooled infants with neonatal hypoxic ischemic encephalopathy results in a higher risk of prespecified serious adverse events (SAEs). 500 infants born at ≥36 weeks of gestation with moderate or severe hypoxic ischemic encephalopathy undergoing therapeutic hypothermia were randomized to Epo or placebo on days 1, 2, 3, 4 and 7.