
Bryan Bogin
Articles
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Mar 3, 2025 |
dx.doi.org | Bryan Bogin |Zachary Levine
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Jul 6, 2024 |
biorxiv.org | Zachary Levine |Bryan Bogin
AbstractDrugging intrinsically disordered proteins (IDPs) has historically been a major challenge due to their lack of stable binding sites, conformational heterogeneity, and rapid ability to self-associate or bind non-specific neighbors. Furthermore, it is unclear whether binders of disordered proteins i) induce entirely new conformations or ii) target transient pre-structured conformations via stabilizing existing states.
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