Bryan Davies

Sep 10, 2024 | cell.com | Bryan Davies

Keywordsmicrocinimmunity proteinVibrio choleraebacterial competitionantibacterialbacteriocininfectious diseaseproteaseGet full text accessLog in, subscribe or purchase for full access. References1. Baquero, F. ∙ Lanza, V.F. ∙ Baquero, M.-R. ... Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal ChemosphereFront. Microbiol. 2019; 10:22612.

Aug 15, 2024 | oncodaily.com | Luiz Vieira |Claus O. Wilke |Bryan Davies

Samuel Hume, Researcher at the University of Oxford, recently shared on X:“The 10 biggest medical research papers from this week (in my opinion!)1. A blood test for Alzheimer disease, which improved diagnostic accuracy – by dementia specialists – from 73% to 91%. ‘Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care‘2.

May 4, 2024 | simcoe.com | Bryan Davies

On April 29, members, friends and charity partners gathered at the ReMax Room in the new Wasaga Beach Arena to celebrate the 40th anniversary of the Rotary Club of Wasaga Beach. Congratulations from the Town of Wasaga Beach were delivered by Deputy Mayor Tanya Snell, and a representative from MP Terry Dowdall’s office presented certificates to members who received Community Service Awards.

Nov 15, 2023 | biorxiv.org | Anastasiya V Kulikova |Jennifer Parker |Bryan Davies |Claus O. Wilke

AbstractClass II microcins are antimicrobial peptides that have shown some potential as novel antibiotics. However, to date only ten class II microcins have been described, and discovery of novel microcins has been hampered by their short length and high sequence divergence. Here, we ask if we can use numerical embeddings generated by protein large language models to detect microcins in bacterial genome assemblies and whether this method can outperform sequence-based methods such as BLAST.

Sep 10, 2023 | biorxiv.org | Justin R. Randall |Luiz Vieira |Claus O. Wilke |Bryan Davies

AbstractAntimicrobial peptides commonly act by disrupting bacterial membranes, but also frequently damage mammalian membranes. Deciphering the rules governing membrane selectivity is critical to understanding their function and enabling their therapeutic use. Past attempts to decipher these rules often fail because they cannot interrogate adequate peptide sequence variation.