Bryan R. Gorman

Oct 4, 2024 | digitalcommons.library.tmc.edu | Jinyoung Byun |Bryan R. Gorman |Sun-Gou Ji |Michael Francis

AbstractLung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remains challenging.

Oct 3, 2024 | nature.com | Bryan R. Gorman |Sun-Gou Ji |Michael Francis |Anoop K. Sendamarai |Elizabeth S. Partan |Jinyoung Byun | +6 more

AbstractLung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remains challenging.

Jun 12, 2024 | nature.com | Aoxing Liu |Giulio Genovese |Yajie Zhao |Matti Pirinen |Xiaoxi Liu |Bryan R. Gorman | +15 more

AbstractMosaic loss of the X chromosome (mLOX) is the most common clonal somatic alteration in leukocytes of female individuals1,2, but little is known about its genetic determinants or phenotypic consequences. Here, to address this, we used data from 883,574 female participants across 8 biobanks; 12% of participants exhibited detectable mLOX in approximately 2% of leukocytes. Female participants with mLOX had an increased risk of myeloid and lymphoid leukaemias.

Apr 26, 2024 | medrxiv.org | Jinyoung Byun |Bryan R. Gorman |Michael Francis |Sun-Gou Ji

S.-G.J. is an employee and shareholder of BridgeBio Pharma. The other authors declare no competing interests. This work was supported by award #MVP000 from the United States Department of Veterans Affairs (VA) Million Veteran Program. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Apr 25, 2024 | medrxiv.org | Michael Francis |Bryan R. Gorman |Tim B. Bigdeli |Giulio Genovese

A.G.B. is on the scientific advisory board of TenSixteen Bio unrelated to the present work.