Byungwoo Ryu

1 week ago | biorxiv.org | Jaemin Byun |Byungwoo Ryu |Abdul Khan |Soojin Kim

AbstractThe CoREST complex is a multi-subunit epigenetic regulator implicated in histone modification and transcriptional repression, but its role in tumorigenesis is not well-defined. Here, we show that the CoREST complex directly interacts with and stabilizes the MYC oncoprotein in cancer cells through site-specific deacetylation of lysine residues, primarily mediated by HDAC1/2.