Camryn D Schmelzer

1 month ago | biorxiv.org | Sean Merriman |Mary Chapman |Joseph Stewart |Camryn D Schmelzer

AbstractIn earlier studies, we optimized an assay system for the genome-wide detection of copy number variation (CNV) in diploid Saccharomyces cerevisiae cells, based on selection for formaldehyde plus copper (FA+Cu) resistance conferred by the amplification of a dosage-dependent reporter cassette, SFA1-CUP1. Our analyses identified a robust bias for terminal deletions of the right arm of Chr7 (Chr7R) associated with unbalanced translocations.