Canan Durukan

2 months ago | onlinelibrary.wiley.com | Canan Durukan |Juan Perez |Juan Perez |Sven Hennig |Jannik Faierson

1 Introduction In solution, short peptides exhibit high conformational flexibility, predominantly existing as random coil structures [1]. Upon interaction with biomolecular binding partners, however, peptide ligands often adopt well-defined conformations [2]. The stabilization of peptide ligands in this bound-like, bioactive confirmation has been used to enhance target affinity and bioactivity.