Carina Meyer

2 months ago | cell.com | Rocio Vicario |Stamatina Fragkogianni |Maria Pokrovskii |Carina Meyer |Estibaliz Lopez-Rodrigo |Yang Hu | +31 more

Keywords Neurodegeneration MAPK pathway microglia hippocampus brainstem resident macrophages Introduction Langerhans cell histiocytosis (LCH)1 and Erdheim-Chester disease (ECD)2,3 are rare clonal myeloid disorders, with an estimated incidence of ∼5 cases per million people per year.4 They are sometimes co-diagnosed in the same patients,5 and both associated with a high prevalence of the BRAFV600E mutation1,2,3,6,7,8 as well as an increased risk of neurodegenerative disease...