Carina Pizzano

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Holographic stimulation of opposing amygdala ensembles bidirectionally modulates valence-specific behavior via mutual inhibition

Dec 11, 2023 | cell.com | Sean C. Piantadosi |Zhe Charles Zhou |Carina Pizzano |Christian Pedersen

Highlights•Valence-specific ensembles within the BLA are stable and optically separable•Holographic stimulation of BLA neurons through a GRIN lens is specific and robust•Multiphoton stimulation of valence-specific ensembles bidirectionally alters behavior•Opposing ensembles exhibit mutual inhibitory connectivity in vivoSummaryThe basolateral amygdala (BLA) is an evolutionarily conserved brain region, well known for valence processing.

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