Carla Abrahamian

Nov 18, 2024 | nature.com | Carla Abrahamian |Eva-Maria Weiden |Maria S. Soengas |Thomas C. Frohlich |Cheng-Chang Chen |Karin Bartel | +2 more

AbstractMelanoma arising from pigment-producing melanocytes is the deadliest form of skin cancer. Extensive ultraviolet light exposure is a major cause of melanoma and individuals with low levels of melanin are at particular risk. Humans carrying gain-of-function polymorphisms in the melanosomal/endolysosomal two-pore cation channel TPC2 present with hypopigmentation, blond hair, and albinism.