Carleigh Nesbit

Dec 4, 2024 | biorxiv.org | Candice Byers |Whitney Martin |Anne Czechanski |Carleigh Nesbit

AbstractThe kinesin family member 18A (KIF18A) is an essential regulator of microtubule dynamics and chromosome alignment during mitosis. Functional dependency on KIF18A varies by cell type and genetic context but the heritable factors that influence this dependency remain unknown. To address this, we took advantage of the variable penetrance observed in different mouse strain backgrounds to screen for loci that modulate germ cell depletion in the absence of KIF18A.