Carly K. Schissel

Oct 3, 2023 | biorxiv.org | Alanna Schepartz |Leah Roe |Carly K. Schissel |Taylor L. Dover

AbstractProteins and polypeptides containing extended backbone monomers embody highly desirable structures and functions, but they cannot yet be biosynthesized in cells. There are two challenges at work. First is the ribosome, whose ability to promote rapid bond-forming reactions to and from anything other than an α-amino acid or α-hydroxy acid is unknown. The second challenge is the absence of orthogonal enzymes that acylate tRNA with extended backbone monomers.