Carol Lyn Piazza

Nov 8, 2024 | biorxiv.org | David Vance |Grace Freeman-Gallant |Kathleen McCarthy |Kathleen Mccarthy |Carol Lyn Piazza

AbstractBroadly protective immunity to the Lyme disease spirochete, Borreliella burgdorferi, is constrained by an overwhelming antibody response against type-specific epitopes on Outer surface protein C (OspC), a homodimeric helix-rich lipoprotein essential for early stages of spirochete dissemination in vertebrate hosts. However, the molecular basis for type-specific immunity has not been fully elucidated.