Carolin M Sauer

Oct 16, 2023 | nature.com | Carolin M Sauer |James Hall |Dominique-Laurent Couturier |Thomas Bradley |Ashley Sawle |Matthew Eldridge | +6 more

AbstractHigh-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical utility in HGSOC. However, the prevalence of CA in HGSOC, its relationship to genomic biomarkers of CIN and its potential impact on therapeutic response have not been defined.

Jul 6, 2023 | nature.com | Carolin M Sauer |Jose Espejo Valle-Inclan |Thomas Mitchell

AbstractCharacterization of somatic mutations at single-cell resolution is essential to study cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an algorithm designed for the detection of somatic mutations in single-cell transcriptomic and ATAC-seq (assay for transposase-accessible chromatin sequence) data sets directly without requiring matched bulk or single-cell DNA sequencing data.