Caroline Wilson

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Articles

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

Sep 18, 2023 | biorxiv.org | Chris Hsiung |Caroline Wilson |Raymond Dai |Nicholas A Sambold

AbstractMultiplexed genetic perturbations are critical for testing functional interactions among coding or non-coding genetic elements. Compared to DNA cutting, repressive chromatin formation using CRISPR interference (CRISPRi) avoids genotoxicity and is more effective for perturbing non-coding regulatory elements in pooled assays. However, current CRISPRi pooled screening approaches are generally limited to targeting 1-3 genomic sites per cell.
Role of Peripheral Inflammation in Risk of Suicide

Apr 10, 2023 | biologicalpsychiatryjournal.com | Shengnan Sun |Qingkun Liu |Zhaoyu Wang |Caroline Wilson

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