Carolyn E Cesta

2 months ago | jamanetwork.com | Jacqueline Cohen |SARAH RADFORD and JENNIFER DONALD |Sarah Mac Donald |Carolyn E Cesta

Key PointsQuestion  Is the use of nicotine replacement therapy (NRT), varenicline, and bupropion during the first trimester of pregnancy associated with increased risks of major congenital malformations (MCMs)? Findings  In this cohort study of 5.2 million births in Australia (state of New South Wales), New Zealand, Norway, and Sweden, there was no increased risk of MCMs overall following exposure to NRT (9325 infants), varenicline (3031 infants), or bupropion (1042 infants).

Dec 11, 2023 | jamanetwork.com | Carolyn E Cesta |Ran S. Rotem |Brian Bateman |Gabriel Chodick

Key PointsQuestion  Is periconceptional use of glucagon-like peptide 1 (GLP-1) receptor agonists or other noninsulin second-line antidiabetic medications (ADMs) associated with increased risk of major congenital malformations?

Jul 17, 2023 | onlinelibrary.wiley.com | Carolyn E Cesta |Sonia Hernández-Díaz |Krista F Huybrechts |Brian Bateman

Statistical analysis To assess representativeness of the HbA1c subset, we compared their distribution of covariates with that of pregnancies in the full T2DM cohort using standardized differences.